The BCS (Basic Chemical Space) Screen developed at theStructural Genomic Consortium (SGC), Oxfordhas a novel approach to screening. PEGs are grouped by molecular weight and mixed to create fourPEG Smears*(available to purchase separately). The Smears cover a broader range of chemical space while reducing the number of PEG variables.The benefit of using PEG smears is that it reduces the number of PEG variables while maintaining a large coverage of PEG space.
The bottom line is that in tests at the SGC with 191 human proteins, the BCS Screen had a 42% hit rate with only 96 conditions. Many of these proteins had failed to crystallize in other screens.
PEG Smears for broader chemical space coverage牛津大學結構基因組聯盟(SGC)開發的BCS(基本化學空間)篩選有一種新穎的篩選方法。PEG按分子量分組并混合以創建四個PEG涂片*(可單獨購買)。涂片覆蓋了更廣泛的化學空間，同時減少了PEG變量的數量。使用PEG涂片的好處是，它減少了PEG變量的數量，同時保持了較大的PEG空間覆蓋率。
底線是，在SGC對191種人類蛋白質的測試中，BCS篩選在僅96種條件下的命中率為42%。這些蛋白質中有許多在其他篩選中無法結晶。
| Product # | Product Name | Unit Size | Unit Price | | |
|---|
| MD1-104 | The BCS Screen | 96 x 10 ml | | | |
| MD1-104-ECO | The BCS Eco Screen | 96 x 10 ml | | | |
| MD1-105 | The BCS Screen HT-96 | 96 x 1 ml | | | |
| MD1-105-ECO | The BCS Screen HT-96 Eco Screen | 96 x 1 ml | | | |
| MD1-105-FX | The BCS Screen FX pre-filled plate | 96 x 100 μl | | | |
| MD2-100-258 | 50% v/v PEG Smear Low (100ml) | 100 ml | | | |
| MD2-100-259 | 50% v/v PEG Smear Medium (100ml) | 100 ml | | | |
| MD2-100-260 | 50% v/v PEG Smear High (100ml) | 100 ml | | | |
| MD2-100-261 | 50% v/v PEG Smear Broad (100ml) | 100 ml | | | |
| MD2-250-258 | 50% v/v PEG Smear Low (250ml) | 250 ml | | | |
| MD2-250-259 | 50% v/v PEG Smear Medium (250ml) | 250 ml | | | |
| MD2-250-260 | 50% v/v PEG Smear High (250ml) | 250 ml | | | |
| MD2-250-261 | 50% v/v PEG Smear Broad (250ml) | 250 ml | | | |
| MDSR-104- | The BCS Screen Single Reagent | 100 ml | | | |
| MDSR-104-ECO- | The BCS Eco Screen Single Reagent | 100 ml | | | |
| MDSR-105- | The BCS Screen HT-96 Single Reagent | 100 ml | | | |
| MDSR-105-ECO- | The BCS Eco Screen HT-96 Single Reagent | 100 ml | | |
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