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SiliaBond^?羧酸 (Si-CAA) 可用作胺類或碳酸鹽的清除劑，以及醇鹽和有機金屬試劑的淬滅劑。

SiliaBondCarboxylic Acid is primarily used as a weak cation exchanger (WCX) in solid phase extraction (SPE) and in HPLC. It is preferred overSiliaBondTosic Acid(SCX) when performing “Catch and Release” purification technique of compounds bearing a permanent positive charge such as tetraalkylammoniums. Using the SCX in this case could make the release of the compound of interest difficult, not to say irreversible, due to the strong interaction between the two strong ioins.SiliaBondCarboxylic Acid has a pka of ≈4.5. It can also be used in ion exchange chromatography (IEC) and has a different selectivity thanSiliaBondTosic Acid (SCX).^1,2