Anti-BIN1PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-BIN1 Polyclonal Antibody品牌：solarbio | 貨號：K006680P| 英文名稱 | Anti-BIN1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | AMPH2;AMPHL;SH3P9 |
| 應用 | WB |
| 稀釋比例 | WB 1:200-1000. |
| 交叉反應 | Human |
| 蛋白分子量 | 65kDa |
| Gene ID | 274 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human BIN1 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human BIN1 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | O00499 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. |
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