Anti-Phospho-PRKACA-T197PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-Phospho-PRKACA-T197 Polyclonal Antibody品牌：solarbio | 貨號：K006238P| 英文名稱 | Anti-Phospho-PRKACA-T197 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | PKACA;PPNAD4 |
| 應用 | WB |
| 稀釋比例 | WB 1:500-2000. |
| 交叉反應 | Human Mouse Rat |
| 蛋白分子量 | 41kDa |
| Gene ID | 5566 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A phospho specific peptide corresponding to residues surrounding T197 of human PRKACA |
| 性狀 | 液體 |
| Public Immunogen Range | A phospho specific peptide corresponding to residues surrounding T197 of human PRKACA |
| Subcellular Locations | Cell membrane Cell projection Cytoplasm Lipid-anchor Membrane Mitochondrion Nucleus cilium flagellum |
| Swiss Prot | P17612 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing’s syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. |
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